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How long does it take Boniva to get out of your system? Thank you for your question! The half-life of Boniva is up to 157 hours (approximately 6.5 days). The half-life is the amount of time it takes the body to clear half of the medication. However, once the first 50% is gone, it will take the body up to another 6.5 days to clear 50% of the remaining medication.
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